TAK-659 |CAS:1312691-33-0 Probechem Biochemicals

Chemical Structure : TAK-659

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TAK-659 (Mivavotinib;TAK 659;TAK659)

货号: PC-60450Not For Human Use, Lab Use Only.

TAK-659 (TAK659, Mivavotinib) is a potent, selective and orally available SYK inhibitor with IC50 of 3.2 nM.

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1 g		Get quote

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生物&药学活性

TAK-659 (TAK659, Mivavotinib) is a potent, selective and orally available SYK inhibitor with IC50 of 3.2 nM.
TAK-659 displays 36, 42 and 23-fold selectivity over JAK3, ZAP70 and VEGFR2, respectively.
TAK-659 also potently inhibits FLT-3.
TAK-659 inhibits cellular proliferation in SYK-dependent DLBCL and FLT3-dependent AML cell lines, demonstrates potent tumor growth inhibition in the FLT3-dependent MV4-11 xenograft models.

物理化学性质&存储条件

分子量	344.394
分子式	C17H21FN6O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	6-(((1R,2S)-2-aminocyclohexyl)amino)-7-fluoro-4-(1-methyl-1H-pyrazol-4-yl)-1,2-dihydro-3H-pyrrolo[3,4-c]pyridin-3-one

参考文献

1. Lam B, et al. Bioorg Med Chem Lett. 2016 Dec 15;26(24):5947-5950.

2. Purroy N, et al. Oncotarget. 2017 Jan 3;8(1):742-756.

3. Liu D, et al. J Hematol Oncol. 2017 Jul 28;10(1):145.

TAK-659 (Mivavotinib;TAK 659;TAK659)

生物&药学活性

物理化学性质&存储条件

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TAK-659 (Mivavotinib;TAK 659;TAK659)

生物&药学活性

物理化学性质&存储条件

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