TAK-438 free base |CAS:881681-00-1 Probechem Biochemicals

Chemical Structure : TAK-438 free base

CAS No.: 881681-00-1

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TAK-438 free base (Vonoprazan;TAK438 free base)

货号: PC-42022Not For Human Use, Lab Use Only.

A novel potent, oral potassium-competitive acid blocker (P-CAB) that potently inhibits H+,K+-ATPase with IC50 of 19 nM.

规格	价格	库存
100 mg	￥560	In stock
500 mg	￥1550	In stock
1g	￥2250	In stock

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生物&药学活性

A novel potent, oral potassium-competitive acid blocker (P-CAB) that potently inhibits H+,K+-ATPase with IC50 of 19 nM; completely inhibits basal and 2-deoxy-d-glucose-stimulated gastric acid secretion in rats (4mg/kg, p.o.); increases the pH of gastric perfusate to a higher value, and sustains longer than those of lansoprazole or SCH28080; a clinical candidate for the treatment of gastroesophageal reflux disease (GERD), peptic ulcer, and other acid-related diseases.

Ulcer

Phase 3 Clinical

物理化学性质&存储条件

分子量	345.3912
分子式	C17H16FN3O2S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	DMSO: ≥ 33 mg/mL
Chemical Name/SMILES	1H-Pyrrole-3-methanamine, 5-(2-fluorophenyl)-N-methyl-1-(3-pyridinylsulfonyl)-

参考文献

1. Arikawa Y, et al. J Med Chem. 2012 May 10;55(9):4446-56.

2. Hori Y, et al. J Pharmacol Exp Ther. 2010 Oct;335(1):231-8.

3. Shin JM, et al. J Pharmacol Exp Ther. 2011 Nov;339(2):412-20.

TAK-438 free base (Vonoprazan;TAK438 free base)

生物&药学活性

物理化学性质&存储条件

参考文献

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TAK-438 free base (Vonoprazan;TAK438 free base)

生物&药学活性

物理化学性质&存储条件

参考文献

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