TAK-285 | HER2/EGFR inhibitor | Probechem Biochemicals

Chemical Structure : TAK-285

CAS No.: 871026-44-7

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TAK-285 (TAK285)

货号: PC-23313Not For Human Use, Lab Use Only.

TAK-285 is a potent, dual inhibitor of HER2 and EGFR (HER1) with IC50 of 17 nM and 23 nM, respectively.

规格	价格	库存
5 mg	￥1480	In stock
10 mg	￥2180	In stock
25 mg	￥3880	In stock
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

TAK-285 is a potent, dual inhibitor of HER2 and EGFR (HER1) with IC50 of 17 nM and 23 nM, respectively.
TAK-285 is >10-fold selectivity for HER1/2 than HER4, and less potent to MEK1/5, c-Met, Aurora B, Lck, CSK etc.
TAK-285 shows significant growth inhibitory activity against BT-474 cells (HER2-overexpressing human breast cancer cell line) with GI50 of 17 nM.
TAK-285 (50-100 mg/kg; oral administration; twice daily; for 14 days; female BALB/cAJcl mice) treatment exhibits dose-dependent tumor growth inhibition (tumor/control ratio [T/C]): 44% and 11% at 50 and 100 mg/kg, respectively) without significant body weight loss in mice.

物理化学性质&存储条件

分子量	547.96
分子式	C26H25ClF3N5O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(2-(4-((3-Chloro-4-(3-(trifluoromethyl)phenoxy)phenyl)amino)-5H-pyrrolo[3,2-d]pyrimidin-5-yl)ethyl)-3-hydroxy-3-methylbutanamide

参考文献

1. Aertgeerts K, et al. J Biol Chem. 2011 May 27;286(21):18756-65.

2. Ishikawa T, et al. J Med Chem. 2011 Dec 8;54(23):8030-50.

TAK-285 (TAK285)

生物&药学活性

物理化学性质&存储条件

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TAK-285 (TAK285)

生物&药学活性

物理化学性质&存储条件

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