TAK-220 | CCR5 antagonist | Probechem Biochemicals

Chemical Structure : TAK-220

CAS No.: 333994-00-6

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TAK-220 (TAK 220, TAK220)

货号: PC-45771Not For Human Use, Lab Use Only.

TAK-220 (TAK220) is a potent, specific, orally bioavailable CCR5 antagonist that blocks the binding of MIP-1α to CCR5 with IC50 of 1.4 nM.

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10 mg	￥4580	In stock
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生物&药学活性

TAK-220 (TAK220) is a potent, specific, orally bioavailable CCR5 antagonist that blocks the binding of MIP-1α to CCR5 with IC50 of 1.4 nM.
TAK-220 shows no affinity for CCR1, CCR2b, CCR3, CCR4, or CCR7.
TAK-220 inhibits the replication of 6 CCR5-using (R5) HIV-1 clinical isolates in peripheral blood mononuclear cells (PBMCs) with mean EC90 of 13 nM.
TAK-220 selectively inhibits R5 HIV-1 replication by interfering with coreceptor-mediated entry of the virus into host cells; exhibits a good pharmacokinetic profile in monkeys.

物理化学性质&存储条件

分子量	553.1353
分子式	C31H41ClN4O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-Piperidinecarboxamide, 1-acetyl-N-[3-[4-[[4-(aminocarbonyl)phenyl]methyl]-1-piperidinyl]propyl]-N-(3-chloro-4-methylphenyl)-

参考文献

1. Tremblay CL, et al. Antimicrob Agents Chemother. 2005 Aug;49(8):3483-5.

2. Takashima K, et al. Antimicrob Agents Chemother. 2005 Aug;49(8):3474-82.

3. Imamura S, et al. J Med Chem. 2006 May 4;49(9):2784-93.

TAK-220 (TAK 220, TAK220)

生物&药学活性

物理化学性质&存储条件

参考文献

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TAK-220 (TAK 220, TAK220)

生物&药学活性

物理化学性质&存储条件

参考文献

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