TACR1 inhibitor C547 (C547-0555)

Chemical Structure : TACR1 inhibitor C547

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货号: PC-27864Not For Human Use, Lab Use Only.

TACR1 inhibitor C547 (C547-0555) is a specific tachykinin receptor 1 (TACR1) inhibitor, selectively suppresses Substance P (SP)-induced growth and proliferation in TACR1-high pancreatic cancer cells, attenuates SP-driven ERK signaling.

规格	价格	库存	数量
25 mg		Get quote
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

TACR1 inhibitor C547 (C547-0555) is a specific tachykinin receptor 1 (TACR1) inhibitor, selectively suppresses Substance P (SP)-induced growth and proliferation in TACR1-high pancreatic cancer cells, attenuates SP-driven ERK signaling.
C547 attenuates SP-induced migration, EMT-associated transcriptional changes, and neurotrophin expression in pancreatic cancer cells.
C547 increases the expression of antigen-presentation- and immune chemokine-associated transcripts, including HLA-A, HLA-B, HLA-C, and CXCL10, under SP-treated conditions.
C547 suppresses SP-induced ERK activation through TACR1-dependent signaling.
C547 (10 mg/kg, i.p.) reduces orthotopic pancreatic tumor growth and tumor innervation in orthotopic pancreatic cancer model.

物理化学性质&存储条件

分子量	409.46
分子式	C23H24FN3O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1-ethyl-4-(2-(4-(4-fluorophenyl)piperazin-1-yl)-2-oxoethoxy)quinolin-2(1H)-one

参考文献

1. Xiao M, et al. ACS Pharmacol Transl Sci. 2026 Aug 3;9(8):2312-2323.