T56-LIMKi |CAS:924473-59-6 Probechem Biochemicals

Chemical Structure : T56-LIMKi

CAS No.: 924473-59-6

加入收藏

T56-LIMKi (T-5601640, T5601640)

货号: PC-45621Not For Human Use, Lab Use Only.

T56-LIMKi (T-5601640) is a specific LIMK2 inhibitor, reduces phosphorylated cofilin (p-cofilin) by LIMK2 but not by LIMK1 and inhibits (IC50=30 uM) the proliferation in NF1−/− MEFs.

规格	价格	库存
10 mg	￥880	In stock
25 mg	￥1580	In stock
50 mg	￥2580	In stock
100 mg		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

T56-LIMKi (T-5601640) is a specific LIMK2 inhibitor, reduces phosphorylated cofilin (p-cofilin) by LIMK2 but not by LIMK1 and inhibits (IC50=30 uM) the proliferation in NF1−/− MEFs.
T56-LIMKi synergizes with salirasib to destabilize the actin cytoskeleton, decreases anchorage-independent cell growth of NF1−/− MEFs.
T56-LIMKi reduces tumor size and p-cofilin levels in a nude mouse Panc-1 xenograft model.

物理化学性质&存储条件

分子量	389.328
分子式	C19H14F3N3O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	DMSO: ≥ 36 mg/mL
Chemical Name/SMILES	5-Isoxazolecarboxamide, 3-methyl-N-[3-[[[3-(trifluoromethyl)phenyl]amino]carbonyl]phenyl]-

参考文献

1. Mashiach-Farkash E, et al. Oncotarget. 2012 Jun;3(6):629-39.

2. Rak R, et al. Cell Cycle. 2014;13(9):1360-1.

3. Rak R, et al. Oncoscience. 2014 Jan 1;1(1):39-48.

T56-LIMKi (T-5601640, T5601640)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

T56-LIMKi (T-5601640, T5601640)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Get Quotation Now

* Indicates a Required FieldYour information is safe with us.