T5342126 hydrochloride |CAS:1280194-06-0 Probechem Biochemicals

Chemical Structure : T5342126 hydrochloride

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T5342126 hydrochloride (T-5342126;T 5342126)

货号: PC-63373Not For Human Use, Lab Use Only.

T5342126 hydrochloride is a potent, selective TLR4 inhibitor, inhibits LPS-induced NO production in RAW 264 macrophage cells with IC50 of 27.8 uM.

规格	价格	库存	数量
25 mg		Get quote
100 mg		Get quote
250 mg		Get quote
1 g		Get quote

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生物&药学活性

T5342126 hydrochloride is a potent, selective TLR4 inhibitor, inhibits LPS-induced NO production in RAW 264 macrophage cells with IC50 of 27.8 uM.
T5342126 shows effectivity in reducing ethanol drinking and inhibiting the activation and proliferation of microglia in both ethanol-dependent and non-dependent mice.

物理化学性质&存储条件

分子量	494.457
分子式	C25H33Cl2N3O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
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Solubility	10 mM in DMSO
Chemical Name/SMILES	1-(((1-(2-chlorobenzyl)-3,5-dimethyl-1H-pyrazol-4-yl)methyl)(methyl)amino)-3-(4-ethoxyphenoxy)propan-2-ol hydrochloride

参考文献

1. Bajo M, et al. Alcohol. 2016 Sep;51(5):541-8.

2. Chavez SA, et al. J Med Chem. 2011 Jul 14;54(13):4659-69.

T5342126 hydrochloride (T-5342126;T 5342126)

生物&药学活性

物理化学性质&存储条件

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T5342126 hydrochloride (T-5342126;T 5342126)

生物&药学活性

物理化学性质&存储条件

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