T417 | PBX1 inhibitor | Probechem Biochemicals

Chemical Structure : T417

CAS No.: 2032123-28-5

加入收藏

T417 (PBX1 inhibitor T417, TCRS-417)

货号: PC-72727Not For Human Use, Lab Use Only.

T417 (PBX1 inhibitor T417, TCRS-417) is a novel small molecule compound capable of docking to the interface between PBX1 and its cognate DNA target sequence, potently interferes with the PBX1-DNA interaction with IC50 of 6.58 uM.

规格	价格	库存
5 mg	￥2480	In stock
10 mg	￥3980	In stock
25 mg	￥5980	In stock
50 mg		Get quote
100 mg		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

T417 (PBX1 inhibitor T417, TCRS-417) is a novel small molecule compound capable of docking to the interface between PBX1 and its cognate DNA target sequence, potently interferes with the PBX1-DNA interaction with IC50 of 6.58 uM.
T417 destabilizes the PBX1-DNA complex, T417 competition of PBX1 protein binding to immobilized PBX1 consensus DNA with IC50 of 5 uM.
T417 selectively suppresses the formation of the PBX1/MEIS2 transcriptional complex, inhibits PBX1 transcriptional activity by hindering its binding to the promoter regions of PBX1 downstream target genes.
T417 (PBX1 inhibitor T417) selectively inhibits carboplatin-resistant tumor cells, and suppresses tumor growth in xenograft models of carboplatin-resistant cancer models.
T417 also is selectively toxic against chr1q-amplified myeloma and solid tumour cells.

物理化学性质&存储条件

分子量	446.434
分子式	C25H19FN2O5
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(4-(2-((3,4-dihydroxyphenyl)amino)-2-oxoethoxy)naphthalen-1-yl)-3-fluorobenzamide

参考文献

1. Shen YA, et al. iScience. 2021 Oct 15;24(11):103297.

2. Trasanidis N, et al. Blood. 2022 Jan 11:blood.2021014391.

T417 (PBX1 inhibitor T417, TCRS-417)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

T417 (PBX1 inhibitor T417, TCRS-417)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Get Quotation Now

* Indicates a Required FieldYour information is safe with us.