T0901317 |CAS:293754-55-9 Probechem Biochemicals

Chemical Structure : T0901317

CAS No.: 293754-55-9

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T0901317 (TO901317;T-0901317)

货号: PC-42684Not For Human Use, Lab Use Only.

T0901317 (TO901317) is a potent, high affinity LXR agonist (EC50=50 nM, Kd are 7 and 22 nM for LXR-α and LXR-β respectively).

规格	价格	库存
10 mg	￥580	In stock
25 mg	￥980	In stock
50 mg	￥1480	In stock
100 mg		Get quote

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生物&药学活性

T0901317 (TO901317) is a potent, high affinity LXR agonist (EC50=50 nM, Kd are 7 and 22 nM for LXR-α and LXR-β respectively).
T0901317 (TO901317) upregulates expression of the ABCA1 gene associated with cholesterol efflux regulation and HDL metabolism.
T0901317 (TO901317) decreases amyloid-β production in primary neurons in vitro.
T0901317 (TO901317) displays an EC50 of ~ 5 μM for activation of FXRs.
T0901317 (TO901317) also is an inverse agonist of human constitutive androstane receptor (hCAR), blocks the interaction of hCAR with steroid receptor co-activator 1 (SRC1).

物理化学性质&存储条件

分子量	481.3327
分子式	C17H12F9NO3S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	DMSO: ≥ 27 mg/mL
Chemical Name/SMILES	Benzenesulfonamide, N-(2,2,2-trifluoroethyl)-N-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]-

参考文献

1. Repa JJ, et al. Science. 2000 Sep 1;289(5484):1524-9.

2. Koldamova RP, et al. J Biol Chem. 2005 Feb 11;280(6):4079-88.

3. Kanno Y, et al. J Toxicol Sci. 2013;38(3):309-15.

T0901317 (TO901317;T-0901317)

生物&药学活性

物理化学性质&存储条件

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T0901317 (TO901317;T-0901317)

生物&药学活性

物理化学性质&存储条件

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