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首页-小分子抑制剂&激动剂-Proteasome/Ubiquitin-E3 Ubiquitin Ligase-T0467
T0467

Chemical Structure : T0467

CAS No.: 859518-94-8

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T0467 (T 0467)

货号: PC-20550Not For Human Use, Lab Use Only.

T0467 is a small molecule activator of PINK1-Parkin signaling, activates Parkin mitochondrial translocation in dopaminergic neurons and myoblasts (20 uM, 3h), does not induce mitochondrial accumulation of PINK1.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

T0467 is a small molecule activator of PINK1-Parkin signaling, activates Parkin mitochondrial translocation in dopaminergic neurons and myoblasts (20 uM, 3h), does not induce mitochondrial accumulation of PINK1.
T0467 stimulates the mitochondrial translocation of Parkin in a PINK1-dependent manner.
T0467 reduces unfolded mitochondrial protein levels, presumably through enhanced PINK1-Parkin signaling.
T0467 mitigates the locomotion defect, reduced ATP production, and disturbed mitochondrial Ca2+ response in the muscles along with the mitochondrial aggregation in dopaminergic neurons through reduced PINK1 activity in Drosophila.

物理化学性质&存储条件

分子量 441.50
分子式 C24H26F3N5
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

FC1=CC(CCNC2=NC(C3=C(F)C=CC(CN4CCNC[C@@H]4C)=C3)=CC=N2)=CC(F)=C1

参考文献

1. Shiba-Fukushima K, et al. iScience. 2020 May 22;23(5):101048.

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