T-518 | HDAC6 inhibitor | Probechem Biochemicals

Chemical Structure : T-518

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T-518 (T518)

货号: PC-72785Not For Human Use, Lab Use Only.

T-518 (T518) is a potent, highly selective, brain penetrant, oral HDAC6 inhibitor with IC50 of 36 nM.

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生物&药学活性

T-518 (T518) is a potent, highly selective, brain penetrant, oral HDAC6 inhibitor with IC50 of 36 nM.
T-518 did not obviously inhibit human HDAC1, 4, or 7 at 10 uM, which belongs to Class I or Class IIa HDAC.
T-518 showed brain penetration in an oral dose and blocked HDAC6-dependent tubulin deacetylation at Lys40 in mouse hippocampus.
T-518 decreased RIPA-insoluble tau accumulation (3-month treatment, 1 and 3 mg/kg), restored impaired axonal transport and novel object recognition in the P301S tau Tg mouse (tauopathy model) by 2-week treatment with dose 1 and 3 mg/kg.

物理化学性质&存储条件

分子量	495.358
分子式	C19H16F7N5O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-[(1R,2R)-2-[3-[5-(Difluoromethyl)-1,3,4-oxadiazol-2-yl]-5,7-dihydro-5-oxo-6H-pyrrolo[3,4-b]pyridin-6-yl]cyclohexyl]-2,2,3,3,3-pentafluoropropanamide

参考文献

1. Tomohiro Onishi, et al. Sci Rep. 2021 Jul 29;11(1):15423.

T-518 (T518)

生物&药学活性

物理化学性质&存储条件

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T-518 (T518)

生物&药学活性

物理化学性质&存储条件

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