T-3861174 | prolyl tRNA synthetase inhibitor | Probechem Biochemicals

Chemical Structure : T-3861174

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T-3861174 (T3861174)

货号: PC-63354Not For Human Use, Lab Use Only.

T-3861174 is a small molecule prolyl tRNA synthetase (PRS) inhibitor with binding IC50 of 2.3 nM.

规格	价格	库存	数量
25 mg		Get quote
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

T-3861174 is a small molecule prolyl tRNA synthetase (PRS) inhibitor with binding IC50 of 2.3 nM.
T-3861174 induces cell death in several tumor cell lines including SK-MEL-2 (IC50=0.1 uM) without complete suppression of translation, T-3861174-induced cell death was caused by activation of the GCN2-ATF4 pathway.
T-3861174 exhibits significant tumor growth inhibition in SK-MEL-2, G-361, and HT-1080 xenograft models without severe body weight losses.

物理化学性质&存储条件

分子量	472.524
分子式	C26H25FN6O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-4-(3-cyano-3-cyclopropyl-2-oxopyrrolidin-1-yl)-N-(3-fluoro-5-(1-methyl-1H-pyrazol-4-yl)benzyl)-6-methylpicolinamide

参考文献

1. Arita T, et al. Biochem Biophys Res Commun. 2017 Jul 8;488(4):648-654.

T-3861174 (T3861174)

生物&药学活性

物理化学性质&存储条件

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T-3861174 (T3861174)

生物&药学活性

物理化学性质&存储条件

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