T-226296 |CAS:331758-35-1 Probechem Biochemicals

Chemical Structure : T-226296

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T-226296 (T226296)

货号: PC-61529Not For Human Use, Lab Use Only.

T-226296 is a potent, selective, non-peptide antagonist of MCHR1 (Melanin-concentrating hormone receptor 1) with IC50 of 5.5 nM and 8.6 nM for human and rat MCHR1, respectively.

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生物&药学活性

T-226296 is a potent, selective, non-peptide antagonist of MCHR1 (Melanin-concentrating hormone receptor 1) with IC50 of 5.5 nM and 8.6 nM for human and rat MCHR1, respectively.
T-226296 shows high selectivity over other receptors, including MCHR2.
T-226296 reverses the MCH-mediated inhibition of forskolin-stimulated cAMP accumulation, inhibits MCH-induced intracellular Ca2+ increase, and also inhibits MCH-stimulated arachidonic acid release in CHO cells.
T-226296 completely suppresses the food intake induced by MCH in rats (30mg/kg); orally active.

物理化学性质&存储条件

分子量	402.513
分子式	C26H27FN2O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-[6-[(dimethylamino)methyl]-5,6,7,8-tetrahydronaphthalen-2-yl]-4-(4-fluorophenyl)benzamide

参考文献

1. Takekawa S, et al. Eur J Pharmacol. 2002 Mar 8;438(3):129-35.

2. Basso AM, et al. Eur J Pharmacol. 2006 Jul 1;540(1-3):115-20.

3. Kowalski TJ, et al. Eur J Pharmacol. 2004 Aug 16;497(1):41-7.

T-226296 (T226296)

生物&药学活性

物理化学性质&存储条件

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T-226296 (T226296)

生物&药学活性

物理化学性质&存储条件

参考文献

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