Synucleozid | α-synuclein inhibitor | Probechem Biochemicals

Chemical Structure : Synucleozid

CAS No.: 502139-01-7

加入收藏

Synucleozid (NSC 377363)

货号: PC-73134Not For Human Use, Lab Use Only.

Synucleozid (NSC 377363) is a small molecule that targets the IRE structure and inhibits SNCA gene translation in cells, directly targets the α-synuclein mRNA 5'UTR at the designed site.

规格	价格	库存
5 mg	￥2480	In stock
10 mg	￥3980	In stock
50 mg	￥8780	In stock
100 mg		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

Synucleozid (NSC 377363) is a small molecule that targets the IRE structure and inhibits SNCA gene translation in cells, directly targets the α-synuclein mRNA 5'UTR at the designed site.
Synucleozid decreases 2-AP emission with an EC50 of 2.7 uM.
Synucleozid binds and stabilizes the SNCA IRE in cells at a specific structural element.
Synucleozid selectively reduces α-synuclein protein levels by decreasing the amount of SNCA mRNA loaded into polysomes, mechanistically providing a cytoprotective effect in cells.

物理化学性质&存储条件

分子量	368.444
分子式	C22H20N6
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-(4-((4-carbamimidoylphenyl)amino)phenyl)-1H-indole-6-carboximidamide

参考文献

1. Zhang P, et al. Proc Natl Acad Sci U S A. 2020 Jan 21;117(3):1457-1467.

Synucleozid (NSC 377363)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Synucleozid (NSC 377363)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Get Quotation Now

* Indicates a Required FieldYour information is safe with us.