Synta66 |CAS:835904-51-3 Probechem Biochemicals

Chemical Structure : Synta66

CAS No.: 835904-51-3

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Synta66 (Synta 66;Synta-66;S66;GSK1349571A)

货号: PC-60224Not For Human Use, Lab Use Only.

Synta66 (GSK1349571A) is a potent, selective CRAC channel Orai1 blocker with IC50 of 3 uM.

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5 mg	￥1180	In stock
10 mg	￥1780	In stock
25 mg	￥2980	In stock
50 mg	￥4880	In stock
100 mg		Get quote

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生物&药学活性

Synta66 (GSK1349571A) is a potent, selective CRAC channel Orai1 blocker with IC50 of 3 uM.
Synta66 does not impair other plasma membrane ion transporters; inhibits antigen-evoked Ca2+ influx in Fura-2-loaded cells at 10 uM, prevents the increase in Syk activity triggered by Ca2+ entry.
Synta66 reduces FcεRI-dependent Ca(2+) influx and the release of histamine, leukotriene C4, and cytokines (IL-5/-8/-13 and TNFα) by up to 50% at 3 uM in HLMCs.

物理化学性质&存储条件

分子量	352.37
分子式	C20H17FN2O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(2',5'-Dimethoxy[1,1'-biphenyl]-4-yl)-3-fluoro-4-pyridinecarboxamide

参考文献

1. Ng SW, et al. J Biol Chem. 2008 Nov 14;283(46):31348-55.

2. Ashmole I, et al. J Allergy Clin Immunol. 2012 Jun;129(6):1628-35.e2.

3. Nurbaeva MK, et al. Sci Rep. 2015 Oct 30;5:15803.

Synta66 (Synta 66;Synta-66;S66;GSK1349571A)

生物&药学活性

物理化学性质&存储条件

参考文献

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Synta66 (Synta 66;Synta-66;S66;GSK1349571A)

生物&药学活性

物理化学性质&存储条件

参考文献

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