SyntOFF

Chemical Structure : SyntOFF

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货号: PC-25307Not For Human Use, Lab Use Only.

SyntOFF is a specific small molecule inhibitor of syntenin with IC50 of 37 uM in HTRF assays, targets the PDZ2 domain of syntenin.

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生物&药学活性

SyntOFF is a specific small molecule inhibitor of syntenin with IC50 of 37 uM in HTRF assays, targets the PDZ2 domain of syntenin.
SyntOFF does not affect Erbin-P0071 or GRASP55-JAM-B complexes in HTRF.
SyntOFF displays a KD value of 130 µM for syntenin-PDZ tandem plus C-terminal domain.
SyntOFF decreased MCF-7 mammosphere formation, with no effect when MCF-7 cells is KO for syntenin expression, interferes with cell migration, proliferation
SyntOFF regulates the loading of exosomes with syntenin-dependent cargo and EpCAM.

物理化学性质&存储条件

分子量	315.81
分子式	C14H18ClNO3S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(3-((4-chlorophenyl)thio)propanoyl)-L-valine

参考文献

1. Leblanc R, et al. J Extracell Vesicles. 2020 Dec;10(2):e12039.

SyntOFF

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SyntOFF

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