Syn-TEF1 |CAS:2135880-19-0 Probechem Biochemicals

Chemical Structure : Syn-TEF1

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Syn-TEF1

货号: PC-63447Not For Human Use, Lab Use Only.

Syn-TEF1 is a molecule actively enables transcription across repressive GAA repeats that silence frataxin expression in Friedreich's ataxia, license transcription elongation at targeted genomic loci.

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生物&药学活性

Syn-TEF1 is a molecule actively enables transcription across repressive GAA repeats that silence frataxin expression in Friedreich's ataxia, license transcription elongation at targeted genomic loci.
Syn-TEF1 targets the DNA sequence 5'-AAGAAGAAG-3', activate FXN expression in primary patient cells and patient-derived fibroblasts, iPSCs, cardiomyocytes, sensory neurons, and mouse xenografts.

物理化学性质&存储条件

分子量	1675.334
分子式	C77H104ClN23O16S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-N-(5-((3-((2-((1-(4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)-29-methyl-2,24,34-trioxo-6,9,12,15,18,-hexaoxa-3,25,29,33-tetraazahexatriacontan-36-yl)carbamoyl)-1-methyl-1H-imidazol-4-yl)amino)-3-oxoprop

参考文献

1. Erwin GS, et al. Science. 2017 Dec 22;358(6370):1617-1622.

Syn-TEF1

生物&药学活性

物理化学性质&存储条件

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Syn-TEF1

生物&药学活性

物理化学性质&存储条件

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