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首页-抗体和重组蛋白-Biosimilar Antibody-Sutimlimab
Sutimlimab

Chemical Structure : Sutimlimab

CAS No.: 2049079-64-1

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Sutimlimab (Anti-human C1s mAb, human IgG4-Kappa; BIVV009)

货号: PC-Ab1041Not For Human Use, Lab Use Only.

Sutimlimab (BIVV009, TNT-009) is a humanized mAb that specifically inhibits the complement (CP)-specific serine protease C1s to evaluate the impact of upstream CP antagonism on activation and proliferation of normal and autoimmune human B cells. Sutimlimab potentially reduce RBC lysis, significantly inhibited complement-mediated activation and proliferation of primary human B cells. antagonism suppressed human Ig-induced activation of B cells derived from patients with rheumatoid arthritis..

规格 价格 库存 数量
1 mg ￥3580 In stock
5 mg ￥7580 In stock
10 mg ￥12800 In stock
100 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Sutimlimab (BIVV009, TNT-009) is a humanized mAb that specifically inhibits the complement (CP)-specific serine protease C1s to evaluate the impact of upstream CP antagonism on activation and proliferation of normal and autoimmune human B cells. Sutimlimab potentially reduce RBC lysis, significantly inhibited complement-mediated activation and proliferation of primary human B cells. antagonism suppressed human Ig-induced activation of B cells derived from patients with rheumatoid arthritis.

物理化学性质&存储条件

分子量
分子式 Human IgG4-Kappa
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

PBS, pH 7.0 Contains no stabilizers or preservatives
Chemical Name/SMILES

Sutimlimab; BIVV009; BIVV 009; TNT-009; TNT009; 2049079-64-1; C1 complement complex; complement subcomponent C1

参考文献

1. 1, Jäger U, et al. Blood. 2019 Feb 28;133(9):893-901. 2, Barcellini W, et al. J Clin Med. 2020 Nov 27;9(12):3859.  3, Röth A, et al. N Engl J Med. 2021 Apr 8;384(14):1323-1334. 4, Nikitin PA, et al. J Immunol. 2019 Feb 15;202(4):1200-1209.  5, Gelbenegger G, et al. Blood Adv. 2020 Mar 24;4(6):997-1005.

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