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首页-小分子抑制剂&激动剂-Antibiotics and Antivirals-Influenza Virus-Suraxavir marboxil
Suraxavir marboxil

Chemical Structure : Suraxavir marboxil

CAS No.: 2364589-86-4

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Suraxavir marboxil (GP681, GP-681)

货号: PC-24187Not For Human Use, Lab Use Only.

Suraxavir marboxil (GP681) is an orally bioavailable antiviral drug inhibiting the polymerase acidic protein (PA) of RNA polymerase of influenza virus, demonstrates nanomolar antiviral activity against both influenza A and B viruses with the average IC50 on the transcriptional activity of 0.6 nM, EC90 of 6.9 ng/mL.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

Suraxavir marboxil (GP681) is an orally bioavailable antiviral drug inhibiting the polymerase acidic protein (PA) of RNA polymerase of influenza virus, demonstrates nanomolar antiviral activity against both influenza A and B viruses with the average IC50 on the transcriptional activity of 0.6 nM, EC90 of 6.9 ng/mL.
suraxavir showed viral suppression comparable to oseltamivir and baloxavir.

物理化学性质&存储条件

分子量 597.59
分子式 C29H25F2N3O7S
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(((R)-12'-((S)-7,8-difluoro-6,11-dihydrodibenzo[b,e]thiepin-11-yl)-6',8'-dioxo-6',8',12',12a'-tetrahydro-1'H,4'H-spiro[cyclopropane-1,3'-[1,4]oxazino[3,4-c]pyrido[2,1-f][1,2,4]triazin]-7'-yl)oxy)methyl methyl carbonate

参考文献

1. Wang Y, et al. Nat Med. 2025 Feb;31(2):639-646.

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