Suramin sodium salt |CAS:129-46-4 Probechem Biochemicals

Chemical Structure : Suramin sodium salt

CAS No.: 129-46-4

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Suramin sodium salt (Suramin hexasodium salt, BAY-205, NF-060)

货号: PC-46931Not For Human Use, Lab Use Only.

Suramin sodium salt (BAY-205, NF-060) is an antitrypansomal drug that also possesses antitumor activity, inhibits CRL (Cullin-RING E3 ubiquitin ligases) activity by disrupting its ability to recruit Cdc34.

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10 mg	￥980	In stock
25 mg	￥1580	In stock
50 mg	￥2480	In stock
100 mg	￥4280	In stock
250 mg		Get quote

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生物&药学活性

Suramin sodium salt (BAY-205, NF-060) is an antitrypansomal drug that also possesses antitumor activity, inhibits CRL (Cullin-RING E3 ubiquitin ligases) activity by disrupting its ability to recruit Cdc34.
Suramin also potently inhibits sirtuins: SirT1 (IC50=297 nM), SirT2 (IC50=1.15 μM), and SirT5 (IC50=22 μM).
Suramin induces accumulation of CRL substrates.
Suraminalso inhibits multiple viruses (ZIKVs, EV71).

物理化学性质&存储条件

分子量	1429.171
分子式	C51H34N6Na6O23S6
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	H2O: ≥ 200 mg/mL; DMSO: 5.6 mg/mL (Need warming)
Chemical Name/SMILES	1,3,5-Naphthalenetrisulfonic acid, 8,8'-[carbonylbis[imino-3,1-phenylenecarbonylimino(4-methyl-3,1-phenylene)carbonylimino]]bis-, sodium salt (1:6)

参考文献

1. Wu K, et al. Proc Natl Acad Sci U S A. 2016 Apr 5;113(14):E2011-8.

2. Ren P, et al. Sci Rep. 2017 Feb 20;7:42902.

3. Albulescu IC, et al. Antiviral Res. 2017 Jul;143:230-236.

Suramin sodium salt (Suramin hexasodium salt, BAY-205, NF-060)

生物&药学活性

物理化学性质&存储条件

参考文献

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Suramin sodium salt (Suramin hexasodium salt, BAY-205, NF-060)

生物&药学活性

物理化学性质&存储条件

参考文献

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