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首页-小分子抑制剂&激动剂-Immunology/Inflammation-Cyclooxygenase (COX)-Sulindac
Sulindac

Chemical Structure : Sulindac

CAS No.: 38194-50-2

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Sulindac (MK-231, MK231)

货号: PC-27217Not For Human Use, Lab Use Only.

Sulindac (MK-231) is a nonsteroidal anti-inflammatory drug (NSAID) and inhibitor of cyclooxygenase-1 (COX-1) and COX-2, inhibits tumor growth via COX-2 suppression, exhibits anti-proliferative and anti-invasive effects and enhances the sensitivity to paclitaxel in ovarian cancer.

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100 mg ￥280 In stock
500 mg ￥580 In stock
1 g ￥880 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Sulindac (MK-231) is a nonsteroidal anti-inflammatory drug (NSAID) and inhibitor of cyclooxygenase-1 (COX-1) and COX-2, inhibits tumor growth via COX-2 suppression, exhibits anti-proliferative and anti-invasive effects and enhances the sensitivity to paclitaxel in ovarian cancer.

物理化学性质&存储条件

分子量 356.41
分子式 C20H17FO3S
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(Z)-2-(5-Fluoro-2-methyl-1-(4-(methylsulfinyl)benzylidene)-1H-inden-3-yl)acetic acid

参考文献

1. Fasching U, et al. Wien Klin Wochenschr Suppl. 1976;59:1-10.

2. Cohen A. Clin Pharmacol Ther. 1976 Aug;20(2):238-40.

3. Chen S, et al. Front Pharmacol. 2025 Apr 30;16:1520771.

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