Sulfotransferase-IN-1 |CAS:2158198-77-5 Probechem Biochemicals

Chemical Structure : Sulfotransferase-IN-1

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Sulfotransferase-IN-1

货号: PC-60170Not For Human Use, Lab Use Only.

The first selective, cell-permeable inhibitor of GAG sulfotransferases with IC50 of 2.0-2.5 uM .

规格	价格	库存	数量
25 mg		Get quote
100 mg		Get quote
500 mg		Get quote
1 g		Get quote

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生物&药学活性

The first selective, cell-permeable inhibitor of GAG sulfotransferases with IC50 of 2.0-2.5 uM ; displays 8- to 18-fold greater specificity for GAG sulfotransferases compared to cytosolic sulfotransferases; decreases chondroitin sulfate-E (CS-E) and overall sulfation levels on cell-surface and secreted chondroitin sulfate proteoglycans (CSPGs), and reverses CSPG-mediated inhibition of axonal growth.

物理化学性质&存储条件

分子量	442.09
分子式	C17H11BrCl2N2O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(E)-3-(3-bromo-4-hydroxy-5-methoxyphenyl)-2-cyano-N-(2,4-dichlorophenyl)acrylamide

参考文献

1. Cheung ST, et al. ACS Chem Biol. 2017 Dec 15;12(12):3126-3133.