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首页-小分子抑制剂&激动剂-Nuclear Receptor/Transcription Factor-Keap1-Nrf2-Sulforaphane
Sulforaphane

Chemical Structure : Sulforaphane

CAS No.: 4478-93-7

Sulforaphane

货号: PC-63001Not For Human Use, Lab Use Only.

Sulforaphane (SFN) is an antioxidant agent that exerts protective effects against cell damage by activating Nrf2.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Sulforaphane (SFN) is an antioxidant agent that exerts protective effects against cell damage by activating Nrf2.
Sulforaphane protects RLE‑6TN cells from oxidative damage, potentially via increasing Nrf2 expression and reducing ROS levels.
Sulforaphane reduces lens epithelial cell growth, migration and viability, and promotes ER stress and autophagy in lens cells.
Sulforaphane also inhibits class I and II HDAC activity and suppresses tumor growth by inducing cell cycle arrest and apoptosis selectively in various cancerous prostate epithelial cells without affecting normal cells.

物理化学性质&存储条件

分子量 177.28
分子式 C6H11NOS2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

1-isothiocyanato-4-(methylsulfinyl)-butane

参考文献

1. Jiao Z, et al. Mol Med Rep. 2017 Jun 6.

2. Kim SH, et al. Oncol Lett. 2017 Jun;13(6):4427-4432.

3. Liu H, et al. J Mol Med (Berl). 2017 May;95(5):553-564.

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