Sulfiredoxin inhibitor J14

Chemical Structure : Sulfiredoxin inhibitor J14

CAS No.: 1043854-13-2

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货号: PC-26685Not For Human Use, Lab Use Only.

J14 is a potent, reversible sulfiredoxin (Srx) inhibitor with IC50 of 8.1 uM.

规格	价格	库存
10 mg	￥880	In stock
25 mg	￥1480	In stock
50 mg	￥2380	In stock
100 mg		Get quote

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生物&药学活性

J14 is a potent, reversible sulfiredoxin (Srx) inhibitor with IC50 of 8.1 uM.
J14 increased the accumulation of sulfinic peroxiredoxins and ROS, which led to oxidative mitochondrial damage and caspase activation, resulting in the death of A549 human lung adenocarcinoma cells.
J14 rendered tumorigenic ovarian cells more susceptible to ROS-mediated death compared with nontumorigenic cells and significantly suppressed the growth of A549 xenografts without acute toxicity.

物理化学性质&存储条件

分子量	517.04
分子式	C28H25ClN4O2S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-(((4-(4-(2-Chlorophenyl)piperazin-1-yl)-6-phenylpyrimidin-2-yl)thio)methyl)benzoic acid

参考文献

1. Kim H, et al. Free Radic Biol Med. 2016 Feb;91:264-74.