Sufugolix | LHRH receptor antagonist | Probechem Biochemicals

Chemical Structure : Sufugolix

CAS No.: 308831-61-0

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Sufugolix (TAK013, TAK-013)

货号: PC-42085Not For Human Use, Lab Use Only.

Sufugolix (TAK-013) is a highly potent and orally bioavailable non-peptide antagonist of luteinizing hormone-releasing hormone (LHRH) receptor with binding and functional IC50 of 0.1 and 0.06 nM for human LHRH, respectively.

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10 mg	￥1380	In stock
25 mg	￥2480	In stock
50 mg	￥3980	In stock
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生物&药学活性

Sufugolix (TAK-013) is a highly potent and orally bioavailable non-peptide antagonist of luteinizing hormone-releasing hormone (LHRH) receptor with binding and functional IC50 of 0.1 and 0.06 nM for human LHRH, respectively.
Sufugolix completely suppresses plasma LH levels in castrated male cynomolgus monkeys at 30 mg/kg dose with sufficient duration of action (>24 h)

物理化学性质&存储条件

分子量	667.7242
分子式	C36H31F2N5O4S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	Urea, N-[4-[1-[(2,6-difluorophenyl)methyl]-1,2,3,4-tetrahydro-5-[[methyl(phenylmethyl)amino]methyl]-2,4-dioxo-3-phenylthieno[2,3-d]pyrimidin-6-yl]phenyl]-N'-methoxy-

参考文献

1. Sasaki S, et al. J Med Chem. 2003 Jan 2;46(1):113-24.

Sufugolix (TAK013, TAK-013)

生物&药学活性

物理化学性质&存储条件

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Sufugolix (TAK013, TAK-013)

生物&药学活性

物理化学性质&存储条件

参考文献

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