Succinyl phosphonate |CAS:26647-82-5 Probechem Biochemicals

Chemical Structure : Succinyl phosphonate

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Succinyl phosphonate

货号: PC-43150Not For Human Use, Lab Use Only.

Succinyl phosphonate is an α-Ketoglutarate phosphoanalogue, α-ketoglutarate dehydrogenase inhibitor, effectively inhibits α-ketoglutarate oxidative decarboxylation.

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50 mg		Get quote
100 mg		Get quote

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生物&药学活性

Succinyl phosphonate is an α-Ketoglutarate phosphoanalogue, α-ketoglutarate dehydrogenase (alpha-KGDHC) inhibitor, effectively inhibits α-ketoglutarate oxidative decarboxylation.
Succinyl phosphonate inhibits both muscle and bacterial α-ketoglutarate dehydrogenase complexes (KGDHC), as well as muscle alpha-ketoglutarate dehydrogenase.
Succinyl phosphonate inhibits the glutamate-induced ROS production in glutamate-stimulated hippocampal neurons in situ; impairs viability of cancer cells in a cell-specific metabolism-dependent manner.

物理化学性质&存储条件

分子量	182.0685
分子式	C4H7O6P
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	Butanoic acid, 4-oxo-4-phosphono-

参考文献

1. Biryukov AI, et al. FEBS Lett. 1996 Mar 11;382(1-2):167-70.

2. Bunik VI, et al. Biochemistry. 2005 Aug 9;44(31):10552-61.

3. Zündorf G, et al. Neuroscience. 2009 Jan 23;158(2):610-6.

4. Bunik VI, et al. Oncotarget. 2016 May 3;7(18):26400-21.