Streptonigrin |CAS:3930-19-6 Probechem Biochemicals

Chemical Structure : Streptonigrin

CAS No.: 3930-19-6

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Streptonigrin (Bruneomycin;NSC 45383)

货号: PC-61919Not For Human Use, Lab Use Only.

Streptonigrin (Bruneomycin, NSC 45383) is a potent, selective, and irreversible PAD4 inactivator with IC50 of 1.87 uM, also binds directly to RAD54 with Kd of 9.1 uM, inhibits ATPase and DNA branch migration activity of RAD54.

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1 mg	￥4580	In stock
2 mg	￥7280	In stock
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10 mg		Get quote

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生物&药学活性

Streptonigrin (Bruneomycin, NSC 45383) is a potent, selective, and irreversible PAD4 inactivator with IC50 of 1.87 uM, also binds directly to RAD54 with Kd of 9.1 uM, inhibits ATPase and DNA branch migration activity of RAD54.
Streptonigrin inhibits branch migration of model Holliday junctions with IC50 of 16.5 uM.
Streptonigrin inhibits ATP hydrolysis with IC50 of 14.4 uM, also binds and inhibits the SUMO-specific protease SENP1.

物理化学性质&存储条件

分子量	506.471
分子式	C25H22N4O8
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(4Z)-5-amino-6-(7-amino-6-methoxy-5,8-dioxoquinolin-2-yl)-4-(4,5-dimethoxy-6-oxocyclohexa-2,4-dien-1-ylidene)-3-methyl-1H-pyridine-2-carboxylic acid

参考文献

1. Hengel SR, et al. Cell Chem Biol. 2017 Sep 21;24(9):1101-1119.

2. Deakyne JS, et al. J Biol Chem. 2013 Nov 1;288(44):31567-80.

3. Dreyton CJ, et al. Bioorg Med Chem. 2014 Feb 15;22(4):1362-9.

4. Knuckley B, et al. Chem Commun (Camb). 2010 Oct 14;46(38):7175-7.

Streptonigrin (Bruneomycin;NSC 45383)

生物&药学活性

物理化学性质&存储条件

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Streptonigrin (Bruneomycin;NSC 45383)

生物&药学活性

物理化学性质&存储条件

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