Steroid sulfatase inhibitor DU-14 is a hihly potent steroid sulfatase inhibitor with IC50 of 55.8 nM, inhibits inhibits the MCF-7 cell proliferation with IC50 of 38.7 nM.
Steroid sulfatase inhibitor DU-14 is a hihly potent steroid sulfatase inhibitor with IC50 of 55.8 nM, inhibits inhibits the MCF-7 cell proliferation with IC50 of 38.7 nM. DU-14 shows neuroprotective effects against neurotoxic Aβ, alleviates Aβ-induced impairments in spatial memory and synaptic plasticity. DU-14 can potentiate the blockade of the amnestic effects of scopolamine by exogenously administered DHEAS. DU-14 enhanced the reversal of amnesia by DHEAS.
