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首页-小分子抑制剂&激动剂-Tyrosine Kinase-Src-Src Inhibitor 1
Src Inhibitor 1

Chemical Structure : Src Inhibitor 1

CAS No.: 179248-59-0

Src Inhibitor 1 (Src Kinase Inhibitor 1;Src-l1)

货号: PC-42303Not For Human Use, Lab Use Only.

A potent, selective dual site inhibitor of Src tyrosine kinase with Ki of 15 nM.

规格 价格 库存 数量
5 mg ¥560 In stock
10 mg ¥760 In stock
25 mg ¥1760 In stock
50 mg ¥3160 In stock

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

A potent, selective dual site inhibitor of Src tyrosine kinase with Ki of 15 nM; has IC50 of 44 nM and 88 nM for Src and Lck, respectively; shows selectivity over VEGFR2 (88-fold) and C-fms (190-fold), also inhibits Csk and Yes with similar potency as Src, no activity against p38α/p38β MAPKs or CK1δ.

物理化学性质&存储条件

分子量 373.40456
分子式 C22H19N3O3
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

DMSO: 6.2 mg/mL (Need ultrasonic)

Chemical Name/SMILES

4-Quinazolinamine, 6,7-dimethoxy-N-(4-phenoxyphenyl)-

参考文献

1. Tian G, et al. Biochemistry. 2001 Jun 19;40(24):7084-91.

2. Bain J, et al. Biochem J. 2007 Dec 15;408(3):297-315.

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