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首页-小分子抑制剂&激动剂-Nuclear Receptor/Transcription Factor-Mineralocorticoid Receptor (MLR)-Spironolactone
Spironolactone

Chemical Structure : Spironolactone

CAS No.: 52-01-7

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Spironolactone (SC9420, SC-9420)

货号: PC-28336Not For Human Use, Lab Use Only.

Spironolactone is a potent aldosterone antagonist that acts on the aldosterone mineralocorticoid receptor (IC50=24 nM) and androgen receptor (IC50=77 nM), promotes podocyte autophagy and regulates pain.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Spironolactone is a potent aldosterone antagonist that acts on the aldosterone mineralocorticoid receptor (IC50=24 nM) and androgen receptor (IC50=77 nM), promotes podocyte autophagy and regulates pain.
Spironolactone improves hypertension-related vascular hypertrophy and remodeling by reducing angiotensin II (Ang II)-induced inflammation.
Spironolactone reduces aldosterone-induced vascular and soft tissue calcification through PIT1-dependent signaling, and alleviates vascular dysfunction in type II diabetic mice by reducing oxidative stress and restoring NO/GC signaling.
Spironolactone interferes with aldosterone biosynthesis in the adrenal cortex and inhibit voltage-dependent Ca2+ channels to exert antihypertensive effects.

物理化学性质&存储条件

分子量 416.58
分子式 C24H32O4S
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

Pregn-4-ene-21-carboxylic acid, 7-(acetylthio)-17-hydroxy-3-oxo-, γ-lactone, (7α,17α)-

参考文献

1. Sakurabayashi-Kitade S, et al. Atherosclerosis. 2009 Sep;206(1):54-60

2. Jakob Voelkl, et al. J Clin Invest. 2013 Feb;123(2):812-22.

3. Ryuzea Miura, et al. J Pharmacol Sci. 2006 Jul;101(3):256-9.

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