Spindlactone B (SPL-B)

Chemical Structure : Spindlactone B

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货号: PC-61361Not For Human Use, Lab Use Only.

Spindlactone B (SPL-B) is a novel small molecule inhibitor of transforming acidic coiled-coil-containing protein 3 (TACC3) that selectively inhibits the nucleation of centrosome microtubules in ovarian cancer cells.

规格	价格	库存	数量
25 mg		Get quote
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

Spindlactone B (SPL-B) is a novel small molecule inhibitor of transforming acidic coiled-coil-containing protein 3 (TACC3) that selectively inhibits the nucleation of centrosome microtubules in ovarian cancer cells.
Spindlactone Bbinds to and inhibits the function of the TACC3-TOGp complex, induces aberrant spindles and mitotic arrest in ovarian cancer cells.
Spindlactone B significantly suppresses tumor growth in vivo and exhibits excellent oral bioavailability.

物理化学性质&存储条件

分子量	454.482
分子式	C27H22N2O5
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	8'-[[Ethyl(4-pyridinylmethyl)amino]methyl]-7'-hydroxy[3,4'-bi-2H-1-benzopyran]-2,2'-dione

参考文献

1. Yao R, et al. Oncogene. 2014 Aug 14;33(33):4242-52.