Spautin-1 |CAS:1262888-28-7 Probechem Biochemicals

Chemical Structure : Spautin-1

CAS No.: 1262888-28-7

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Spautin-1 (Spautin1)

货号: PC-62189Not For Human Use, Lab Use Only.

Spautin-1 is a potent, small molecule inhibitor of autophagy with IC50 of 0.74 uM, inhibits USP10 and USP13 with IC50 of 0.6-0.7 uM, but not USP14.

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5 mg (Free Sample)	￥280	In stock
25 mg	￥1580	In stock
50 mg	￥2480	In stock
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生物&药学活性

Spautin-1 is a potent, small molecule inhibitor of autophagy with IC50 of 0.74 uM, inhibits USP10 and USP13 with IC50 of 0.6-0.7 uM, but not USP14.
Spautin-1 promotes cell death under starvation condition and inhibits autophagic cell death, selectively promotes the degradation of Vps34 complexes, reduces the levels of PtdIns3P in cells, but is not a direct inhibitor of class III PI3 kinase activity.
Spautin-1 promotes the degradation of p53 via inhibition of USP10, which can be inhibited in the presence of MG132.
Spautin-1 sensitizes ovarian cancer cells to cisplatin and PARP inhibitor (olaparib).

物理化学性质&存储条件

分子量	271.271
分子式	C15H11F2N3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	6-fluoro-N-[(4-fluorophenyl)methyl]-4-quinazolinamine

参考文献

1. Liu J, et al. Cell. 2011 Sep 30;147(1):223-34.

2. Li Y, et al. Nat Commun. 2017 Jun 1;8:15752. doi: 10.1038/ncomms15752.

3. Mateo R, et al. J Virol. 2013 Feb;87(3):1312-21.

4. Vakifahmetoglu-Norberg H, et al. Genes Dev. 2013 Aug 1;27(15):1718-30.

Spautin-1 (Spautin1)

生物&药学活性

物理化学性质&存储条件

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Spautin-1 (Spautin1)

生物&药学活性

物理化学性质&存储条件

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