Sparsentan | Dual AT-II and ETA antagonist | Probechem Biochemicals

Chemical Structure : Sparsentan

CAS No.: 254740-64-2

加入收藏

Sparsentan (RE-021, DARA-a)

货号: PC-20515Not For Human Use, Lab Use Only.

Sparsentan (RE-021, DARA-a) is a highly potent dual angiotensin II and endothelin A receptor antagonist with Ki values of 0.8 and 9.3 nM, respectively.

规格	价格	库存
10 mg	￥1980	In stock
25 mg	￥3280	In stock
50 mg	￥5280	In stock
100 mg		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

Sparsentan (RE-021, DARA-a) is a highly potent dual angiotensin II and endothelin A receptor antagonist with Ki values of 0.8 and 9.3 nM, respectively.
Sparsentan dose dependently antagonizes the angiotensin II-induced pressor response with an ED50 value of 0.8 µmol/kg iv and 3.6 µmol/kg po.
Sparsentan also shows efficacious and long acting in the big ET-1-induced pressor model.
Sparsentan causes a significant lowering of blood pressure at the lowest dose tested (10 µmol/kg/day) in spontaneously hypertensive rats.

物理化学性质&存储条件

分子量	592.76
分子式	C32H40N4O5S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	CCCCC(N(CC1=CC=C(C2=C(S(NC3=NOC(C)=C3C)(=O)=O)C=CC=C2)C(COCC)=C1)C4=O)=NC54CCCC5

参考文献

1. Murugesan N, et al. J Med Chem. 2005 Jan 13;48(1):171-9.

Sparsentan (RE-021, DARA-a)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Sparsentan (RE-021, DARA-a)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Get Quotation Now

* Indicates a Required FieldYour information is safe with us.