Sparsentan (RE-021, DARA-a) | Dual AT-II and ETA antagonist

Chemical Structure : Sparsentan

CAS No.: 254740-64-2

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Sparsentan (RE-021, RE021, DARA-a)

货号: PC-20515Not For Human Use, Lab Use Only.

Sparsentan (RE-021, DARA-a) is a highly potent dual angiotensin II and endothelin A receptor antagonist with Ki values of 0.8 and 9.3 nM, respectively.

规格	价格	库存
10 mg	￥780	In stock
25 mg	￥1280	In stock
50 mg	￥1980	In stock
100 mg	￥3280	In stock
250 mg		Get quote

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生物&药学活性

Sparsentan (RE-021, DARA-a) is a highly potent dual angiotensin II and endothelin A receptor antagonist with Ki values of 0.8 and 9.3 nM, respectively.
Sparsentan dose dependently antagonizes the angiotensin II-induced pressor response with an ED50 value of 0.8 µmol/kg iv and 3.6 µmol/kg po.
Sparsentan also shows efficacious and long acting in the big ET-1-induced pressor model.
Sparsentan causes a significant lowering of blood pressure at the lowest dose tested (10 µmol/kg/day) in spontaneously hypertensive rats.

物理化学性质&存储条件

分子量	592.76
分子式	C32H40N4O5S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4'-((2-butyl-4-oxo-1,3-diazaspiro[4.4]non-1-en-3-yl)methyl)-N-(4,5-dimethylisoxazol-3-yl)-2'-(ethoxymethyl)-[1,1'-biphenyl]-2-sulfonamide

参考文献

1. Murugesan N, et al. J Med Chem. 2005 Jan 13;48(1):171-9.

Sparsentan (RE-021, RE021, DARA-a)

生物&药学活性

物理化学性质&存储条件

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Sparsentan (RE-021, RE021, DARA-a)

生物&药学活性

物理化学性质&存储条件

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