Sotrastaurin |CAS:425637-18-9 Probechem Biochemicals

Chemical Structure : Sotrastaurin

CAS No.: 425637-18-9

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Sotrastaurin (AEB071;AEB 071;AEB-071)

货号: PC-42543Not For Human Use, Lab Use Only.

Sotrastaurin (AEB071) is a potent, selective, orally available pan-PKC inhibitor with Ki of 0.22-3.2 nM for PKC isotypes.

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10 mg	￥1280	In stock
25 mg	￥1980	In stock
50 mg	￥2980	In stock
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生物&药学活性

Sotrastaurin (AEB071) is a potent, selective, orally available pan-PKC inhibitor with Ki of 0.22-3.2 nM for PKC isotypes.
Sotrastaurin (AEB071) displays excellent selectivity against a broad panel of kinases (only GSK-3β IC50<1 uM).
Sotrastaurin (AEB071) inhibits early T-cell activation with no general antiproliferative activity, also inhibits β2-integrin-mediated T-cell adhesiveness.
Sotrastaurin (AEB071) prolongs rat heterotopic heart transplant survival in combination with adjunct immunosuppression agents.

物理化学性质&存储条件

分子量	438.4812
分子式	C25H22N6O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1H-Pyrrole-2,5-dione, 3-(1H-indol-3-yl)-4-[2-(4-methyl-1-piperazinyl)-4-quinazolinyl]-

参考文献

1. Evenou JP, et al. J Pharmacol Exp Ther. 2009 Sep;330(3):792-801.

2. Wagner J, et al. J Med Chem. 2009 Oct 22;52(20):6193-6.

3. Budde K, et al. Am J Transplant. 2010 Mar;10(3):571-81.

Sotrastaurin (AEB071;AEB 071;AEB-071)

生物&药学活性

物理化学性质&存储条件

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Sotrastaurin (AEB071;AEB 071;AEB-071)

生物&药学活性

物理化学性质&存储条件

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