Chemical Structure : Sotigalimab
CAS No.: 2305607-45-6
货号: PC-Ab1065Not For Human Use, Lab Use Only.
Sotigalimab (APX005M) is a humanized monoclonal antibody that binds CD40 with high affinity and activates antigen presenting cells (dendritic cells, monocytes and B cells) leading to stimulation of cancer-specific T-cell responses. This CD40 monoclonal antibody with chemotherapy induces T-cell-dependent tumour regression in mice and improves survival, triggers a multifaceted immune response that brings several components of the immune system together to attack the cancer..
规格 | 价格 | 库存 | 数量 |
---|---|---|---|
1 mg | ¥3580 | In stock | |
5 mg | ¥7580 | In stock | |
10 mg | ¥12800 | In stock | |
100 mg | Get quote |
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Sotigalimab (APX005M) is a humanized monoclonal antibody that binds CD40 with high affinity and activates antigen presenting cells (dendritic cells, monocytes and B cells) leading to stimulation of cancer-specific T-cell responses. This CD40 monoclonal antibody with chemotherapy induces T-cell-dependent tumour regression in mice and improves survival, triggers a multifaceted immune response that brings several components of the immune system together to attack the cancer.
分子量 | ||
分子式 | Human IgG1-Kappa | |
外观性状 | Solid | |
储存条件 |
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Solubility |
PBS, pH 7.0 Contains no stabilizers or preservatives |
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Chemical Name/SMILES |
Sotigalimab; APX005M; APX-005M; Cluster of Differentiation 40; CD40/TNFR5; CD40-CD40L agonist antibody. |
1. 1, O'Hara MH, et al. Lancet Oncol. 2021 Jan;22(1):118-131. 2, Filbert EL, et al. Cancer Immunol Immunother. 2021 Jul;70(7):1853-1865. 3, Weiss SA, et al. Clin Cancer Res. 2021 Sep 1;27(17):4757-4767. 4, Djureinovic D, et al. Cancers (Basel). 2021 Mar 15;13(6):1302.
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