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首页-小分子抑制剂&激动剂-Membrane Transporter/Ion Channel-SGLT-Sotagliflozin
Sotagliflozin

Chemical Structure : Sotagliflozin

CAS No.: 1018899-04-1

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Sotagliflozin (LX4211, LX-4211, LP-802034)

货号: PC-44486Not For Human Use, Lab Use Only.

Sotagliflozin (LX4211) is a potent, selective, dual SGLT1/SGLT2 inhibitor with IC50 of 14 nM for hSGLT2.

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5 mg ￥880 In stock
10 mg ￥1280 In stock
25 mg ￥2180 In stock
50 mg ￥3580 In stock
100 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Sotagliflozin (LX4211) is a potent, selective, dual SGLT1/SGLT2 inhibitor with IC50 of 14 nM for hSGLT2.
Sotagliflozin (LX4211) exhibits excellent selectivity over hSGLT1 (IC50=19 uM).
Sotagliflozin (LX4211) inhibits SGLT2 in vitro and urinary glucose reabsorption in vivo.

物理化学性质&存储条件

分子量 424.9382
分子式 C21H25ClO5S
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

β-L-Xylopyranoside, methyl 5-C-[4-chloro-3-[(4-ethoxyphenyl)methyl]phenyl]-1-thio-, (5S)-

参考文献

1. Goodwin NC, et al. J Med Chem. 2009 Oct 22;52(20):6201-4.

2. Zambrowicz B, et al. Clin Pharmacol Ther. 2012 Aug;92(2):158-69.

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