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首页-小分子抑制剂&激动剂-Wnt/Notch/Hedgehog-Smoothened (Smo)-Sonidegib phosphate
Sonidegib phosphate

Chemical Structure : Sonidegib phosphate

CAS No.: 1218778-77-8

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Sonidegib phosphate (NPV-LDE225, LDE225, Erismodegib)

货号: PC-38710Not For Human Use, Lab Use Only.

Sonidegib (Erismodegib, LDE225, NVP-LDE225) is potent, selective, orally available Smoothened (SMO) antagonist, inhibits Hedgehog (Hh) signaling with IC50 of 1.3 nM (mouse) and 2.5 nM (human) in cell-free assays, respectively.

规格 价格 库存 数量
10 mg ￥880 In stock
25 mg ￥1480 In stock
50 mg ￥2380 In stock
100 mg ￥3880 In stock
250 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Sonidegib (Erismodegib, LDE225, NVP-LDE225) is potent, selective, orally available Smoothened (SMO) antagonist, inhibits Hedgehog (Hh) signaling with IC50 of 1.3 nM (mouse) and 2.5 nM (human) in cell-free assays, respectively.
LDE225 treatment also increased sensitivity of ALDH-positive cells to paclitaxel in ovarian cancer.
LDE225 decreased MM cell viability by inducing specific down-regulation of Gli1 and Ptch1, hallmarks of Hh activity.
LDE225 showed antitumor efficacy in combination with bortezomib both in vitro and in vivo in multiple myeloma.

物理化学性质&存储条件

分子量 681.49
分子式 C26H32F3N3O11P2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

N-(6-((2R,6S)-2,6-dimethylmorpholino)pyridin-3-yl)-2-methyl-4'-(trifluoromethoxy)-[1,1'-biphenyl]-3-carboxamide bis(phosphate)

参考文献

1. Pan S, et al. ACS Med Chem Lett. 2010 Mar 16;1(3):130-4.

2. Buonamici S, et al. Sci Transl Med. 2010 Sep 29;2(51):51ra70.

3. Heller E, et al. Cancer Res. 2012 Feb 15;72(4):897-907.

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