Sonidegib (Erismodegib, LDE225) | Smoothened inhibitor

Chemical Structure : Sonidegib

CAS No.: 956697-53-3

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Sonidegib (NPV-LDE225, LDE225, Erismodegib)

货号: PC-38709Not For Human Use, Lab Use Only.

Sonidegib (Erismodegib, LDE225, NVP-LDE225) is potent, selective, orally available Smoothened (SMO) antagonist, inhibits Hedgehog (Hh) signaling with IC50 of 1.3 nM (mouse) and 2.5 nM (human) in cell-free assays, respectively.

规格	价格	库存
10 mg	￥880	In stock
25 mg	￥1480	In stock
50 mg	￥2380	In stock
100 mg	￥3980	In stock
250 mg		Get quote

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生物&药学活性

Sonidegib (Erismodegib, LDE225, NVP-LDE225) is potent, selective, orally available Smoothened (SMO) antagonist, inhibits Hedgehog (Hh) signaling with IC50 of 1.3 nM (mouse) and 2.5 nM (human) in cell-free assays, respectively.
LDE225 treatment also increased sensitivity of ALDH-positive cells to paclitaxel in ovarian cancer.
LDE225 decreased MM cell viability by inducing specific down-regulation of Gli1 and Ptch1, hallmarks of Hh activity.
LDE225 showed antitumor efficacy in combination with bortezomib both in vitro and in vivo in multiple myeloma.

物理化学性质&存储条件

分子量	485.507
分子式	C26H26F3N3O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(6-((2S,6R)-2,6-dimethylmorpholino)pyridin-3-yl)-2-methyl-4'-(trifluoromethoxy)biphenyl-3-carboxamide

参考文献

1. Pan S, et al. ACS Med Chem Lett. 2010 Mar 16;1(3):130-4.

2. Buonamici S, et al. Sci Transl Med. 2010 Sep 29;2(51):51ra70.

3. Heller E, et al. Cancer Res. 2012 Feb 15;72(4):897-907.

Sonidegib (NPV-LDE225, LDE225, Erismodegib)

生物&药学活性

物理化学性质&存储条件

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Sonidegib (NPV-LDE225, LDE225, Erismodegib)

生物&药学活性

物理化学性质&存储条件

参考文献

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