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首页-小分子抑制剂&激动剂-Antibiotics and Antivirals-HCV-Sofosbuvir
Sofosbuvir

Chemical Structure : Sofosbuvir

CAS No.: 1190307-88-0

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Sofosbuvir (GS-7977, PSI-7977)

货号: PC-21356Not For Human Use, Lab Use Only.

Sofosbuvir (GS-7977, PSI-7977) is a prodrug of 2'-F-2'-C-methyluridine monophosphate and HCV NS5B polymerase inhibitor, is active against GT 1a, 1b, and 2a (strain JFH-1) replicons and chimeric replicons containing GT 2a (strain J6), 2b, and 3a NS5B polymerase.

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50 mg ￥1780 In stock
100 mg ￥2880 In stock
200 mg ￥4280 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Sofosbuvir (GS-7977, PSI-7977) is a prodrug of 2'-F-2'-C-methyluridine monophosphate and HCV NS5B polymerase inhibitor, is active against GT 1a, 1b, and 2a (strain JFH-1) replicons and chimeric replicons containing GT 2a (strain J6), 2b, and 3a NS5B polymerase.

物理化学性质&存储条件

分子量 529.46
分子式 C22H29FN3O9P
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(S)-Isopropyl 2-(((S)-(((2R,3R,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-fluoro-3-hydroxy-4-methyltetrahydrofuran-2-yl)methoxy)(phenoxy)phosphoryl)amino)propanoate

参考文献

1. Lam AM, et al. Antimicrob Agents Chemother. 2012 Jun;56(6):3359-68.

2. Sofia MJ, et al. J Med Chem. 2010 Oct 14;53(19):7202-18.

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