Sofnobrutinib (AS-0871) | BTK inhibitor | Probechem Biochemicals

Chemical Structure : Sofnobrutinib

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Sofnobrutinib (AS-0871, AS0871, BTK inhibitor 4b)

货号: PC-35698Not For Human Use, Lab Use Only.

Sofnobrutinib (AS-0871, BTK inhibitor 4b) is a potent, highly selective, non-covalent inhibitor of BTK with IC50 of 4.2 and 0.9 nM against activated and unactivated BTK, respectively.

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生物&药学活性

Sofnobrutinib (AS-0871, BTK inhibitor 4b) is a potent, highly selective, non-covalent inhibitor of BTK with IC50 of 4.2 and 0.9 nM against activated and unactivated BTK, respectively.
BTK inhibitor 4b demonstrates significant efficacy in models in vivo and good ADME and safety profiles.

物理化学性质&存储条件

分子量	498.522
分子式	C26H23FN8O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-(3-{4-Amino-6-[(1-methyl-1H-pyrazol-4-yl)amino]-1,3,5-triazin-2-yl}-2-(hydroxymethyl)phenyl)-6-cyclopropyl-8-fluoroisoquinolin-1(2H)-one

参考文献

1. Kawahata W, et al. J Med Chem. 2018 Oct 11;61(19):8917-8933.

Sofnobrutinib (AS-0871, AS0871, BTK inhibitor 4b)

生物&药学活性

物理化学性质&存储条件

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Sofnobrutinib (AS-0871, AS0871, BTK inhibitor 4b)

生物&药学活性

物理化学性质&存储条件

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