Socrodeucitinib (HS-10374) | TYK2 inhibitor | Probechem Biochemicals

Chemical Structure : Socrodeucitinib

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Socrodeucitinib (HS-10374, HS10374)

货号: PC-25094Not For Human Use, Lab Use Only.

Socrodeucitinib (HS-10374) is a potent, selective, allosteric oral tyrosine kinase 2 (TYK2) inhibitor, binds to the pseudokinase domain of TYK2 with IC50 of 0.633 nM.

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生物&药学活性

Socrodeucitinib (HS-10374) is a potent, selective, allosteric oral tyrosine kinase 2 (TYK2) inhibitor, binds to the pseudokinase domain of TYK2 with IC50 of 0.633 nM.

Socrodeucitinib (HS-10374) shows minimal activity against the catalytic domain of JAK1/2/3 and TYK2, with the IC50 of 5952, 4505, 2567 and >10,000 nM, respectively.

Socrodeucitinib (HS-10374) inhibits subsequent TYK2 downstream signalling pathway events.

Socrodeucitinib (HS-10374) selectively inhibits TYK2 cytokine signalling pathways in psoriasis pathogenesis.

物理化学性质&存储条件

分子量	451.51
分子式	C22H21D3N8O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3-Pyridazinecarboxamide, 6-[(cyclopropylcarbonyl)amino]-4-[[3-(1-cyclopropyl-1H-1,2,4-triazol-3-yl)-2-methoxyphenyl]amino]-N-(methyl-d3)-

参考文献

1. Patent CN113968846 A 2022-01-25. 2. Han L, et al. J Eur Acad Dermatol Venereol. 2026 Jul 28. doi: 10.1111/jdv.70643.

Socrodeucitinib (HS-10374, HS10374)

生物&药学活性

物理化学性质&存储条件

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Socrodeucitinib (HS-10374, HS10374)

生物&药学活性

物理化学性质&存储条件

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