Smurf1 inhibitor A01

Chemical Structure : Smurf1 inhibitor A01

CAS No.: 1007647-73-5

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货号: PC-21766Not For Human Use, Lab Use Only.

Smurf1 inhibitor A01 is a specific small molecule inhibitor of ubiquitin ligase Smad ubiquitination regulatory factor-1 (Smurf1) with Kd of 3.66 nM for interrupting Smurf1-Smad1 interaction, impairs Smurf1-mediated Smad1/5 degradation and stabilizes Smad1/5 protein level.

规格	价格	库存
5 mg	￥880	In stock
10 mg	￥1280	In stock
25 mg	￥2180	In stock
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

Smurf1 inhibitor A01 is a specific small molecule inhibitor of ubiquitin ligase Smad ubiquitination regulatory factor-1 (Smurf1) with Kd of 3.66 nM for interrupting Smurf1-Smad1 interaction, impairs Smurf1-mediated Smad1/5 degradation and stabilizes Smad1/5 protein level.
Smurf1 inhibitor A01 does not affect the protein level of Smad2/3, Smad4, ING2 and the small guanosine triphosphatase RhoA.
Smurf1 inhibitor A01 does not interrupt Smurf2-Smad2 or Smurf2-Smad3 interactions.
Smurf1 inhibitor A01 (2 uM) enhances BMP signaling responsiveness in C2C12 and mouse pre-osteoblasts MC3T3-E1 cells, induces gene expression of ALP, osteocalcin and type I collagen (α1).
Smurf1 inhibitor A01 (10 uM) potentiates BMP-2 induced osteoblastic activity in both C2C12 and MC3T3-E1 cells, potentiates BMP-2 induced ALP enrichment.

物理化学性质&存储条件

分子量	512.93
分子式	C22H20ClF3N4O3S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(4-((4-chloro-3-(trifluoromethyl)phenyl)sulfonyl)piperazin-1-yl)(4-(5-methyl-1H-pyrazol-1-yl)phenyl)methanone

参考文献

1. Yu Cao, et al. Sci Rep. 2014 May 14:4:4965.