Smoothib |CAS:2141958-94-1 Probechem Biochemicals

Chemical Structure : Smoothib

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Smoothib

货号: PC-61149Not For Human Use, Lab Use Only.

Smoothib is a novel potent inhibitor of hedgehog (Hh) signaling (IC50=157±118 nM) and an antagonist of the protein smoothened (Smo), binds to the heptahelical bundle of Smo with Kd of 59 nM.

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生物&药学活性

Smoothib is a novel potent inhibitor of hedgehog (Hh) signaling (IC50=157±118 nM) and an antagonist of the protein smoothened (Smo), binds to the heptahelical bundle of Smo with Kd of 59 nM.
Smoothib inhibits Gli-mediated luciferase expression with IC50 of 1.4 uM in Gli-dependent reporter gene assay.
Smoothib reduces the expression of Hh target genes, and suppresses the growth of Ptch+/- medulloblastoma cells.

物理化学性质&存储条件

分子量	543.675
分子式	C33H33N7O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3-(1H-indol-3-yl)-1-(4-(4-(1-(4-methylbenzyl)-1,6-dihydroimidazo[4,5-c]pyrazol-5-yl)phenyl)piperazin-1-yl)propan-1-one

参考文献

1. Kremer L, et al. Angew Chem Int Ed Engl. 2017 Oct 9;56(42):13021-13025.

Smoothib

生物&药学活性

物理化学性质&存储条件

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Smoothib

生物&药学活性

物理化学性质&存储条件

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