Smo inhibitor SAG | Hedgehog agonist | Probechem Biochemicals

Chemical Structure : Smo inhibitor SAG

CAS No.: 912545-86-9

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Smo inhibitor SAG (SAG, Hedgehog agonist SAG)

货号: PC-43256Not For Human Use, Lab Use Only.

SAG is a small molecule Hedgehog (Hh) pathway agonist with EC50 of 3 nM, specifically binds to the Smoothened (Smo) heptahelical bundle (Kd=59 nM).

规格	价格	库存
5 mg	￥1580	In stock
10 mg	￥2480	In stock
25 mg	￥3980	In stock
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

SAG is a small molecule Hedgehog (Hh) pathway agonist with EC50 of 3 nM, specifically binds to the Smoothened (Smo) heptahelical bundle (Kd=59 nM).
SAG effectively activates Shh target gene transcription through the Smoothened (Smo) protein, acts downstream of Ptch1 in the Hh pathway and counteracts cyclopamine inhibition of Smo.
SAG increases Cldn5 expression, decreases endoneurial capillary permeability, and restores thermal algesia to diabetic mice.
SAG inhibits melanin synthesis in melanocytes and pigmentation in a human skin model.

物理化学性质&存储条件

分子量	490.0594
分子式	C28H28ClN3OS
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	DMSO: ≥ 38 mg/mL
Chemical Name/SMILES	Benzo[b]thiophene-2-carboxamide, 3-chloro-N-[trans-4-(methylamino)cyclohexyl]-N-[[3-(4-pyridinyl)phenyl]methyl]-

参考文献

1. Chen JK, et al. Proc Natl Acad Sci U S A. 2002 Oct 29;99(22):14071-6.

2. Choi H, et al. PLoS One. 2016 Dec 12;11(12):e0168025.

3. Stanton BZ, et al. Nat Chem Biol. 2009 Mar;5(3):154-6.

4. Chapouly C, et al. Cardiovasc Res. 2016 Feb 1;109(2):217-27.

Smo inhibitor SAG (SAG, Hedgehog agonist SAG)

生物&药学活性

物理化学性质&存储条件

参考文献

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Smo inhibitor SAG (SAG, Hedgehog agonist SAG)

生物&药学活性

物理化学性质&存储条件

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