M25 |CAS:1186293-14-0 Probechem Biochemicals

Chemical Structure : Smo antagonist M25

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Smo antagonist M25 (M25)

货号: PC-62170Not For Human Use, Lab Use Only.

Smo antagonist M25 is a potent Smoothened (Smo) receptor antagonist (IC50=5 nM) that inhibits the Hedgehog signaling pathway.

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生物&药学活性

Smo antagonist M25 is a potent Smoothened (Smo) receptor antagonist (IC50=5 nM) that inhibits the Hedgehog signaling pathway.
M25 inhibits Shh induced Gli luciferase reporter activity in Shh-light 2 cells (IC50=5 nM), and antagonizes GSA-10 and SAG-mediated differentiation of the C3H10T1/2 cell line.

物理化学性质&存储条件

分子量	379.5
分子式	C23H29N3O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-[[1-(2-Methoxyphenyl)-1H-indazol-5-yl]methyl]-2-propylpentanamide

参考文献

1. Dessole G, et al. Bioorg Med Chem Lett. 2009 Aug 1;19(15):4191-5.

2. Gorojankina T, et al. Mol Pharmacol. 2013 May;83(5):1020-9.

Smo antagonist M25 (M25)

生物&药学活性

物理化学性质&存储条件

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Smo antagonist M25 (M25)

生物&药学活性

物理化学性质&存储条件

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