SmcR inhibitor PTSP

Chemical Structure : SmcR inhibitor PTSP

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货号: PC-27136Not For Human Use, Lab Use Only.

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生物&药学活性

PTSP is a specific and potent inhibitor of Vibrio LuxR/HapR proteins and LuxR homolog SmcR in Vibrio vulnificus, inhibits quorum sensing in multiple strains of V. vulnificus, V. parahaemolyticus, and V. campbellii.
PTSP significantly reduces protease activity in V. campbellii, V. coralliilyticus, and V. vulnificus, but not in V. cholerae, with IC50 of 6.8 nM, 78.1 nM and 18.3 nM for V. vulnificus strains ATCC 27562, CMPC6 and YJ016.
PTSP has a lower dissociation constant (Kd) for SmcR (0.23 μM) compared to LuxR (0.51 μM).
PTSP binds to SmcR drives allosteric unfolding of the N-terminal DNA-binding domain, induces it's specifically degradation by the ClpAP protease.

物理化学性质&存储条件

分子量	290.36
分子式	C13H10N2O2S2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3-phenyl-1-(thiophen-2-ylsulfonyl)-1H-pyrazole

参考文献

1. Rasal TA, et al. mBio. 2026 Mar 11;17(3):e0344525.

2. Newman JD, et al. Mol Microbiol. 2021 Oct;116(4):1173-1188.