Skp2-2

Chemical Structure : Skp2-2

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货号: PC-21056Not For Human Use, Lab Use Only.

Skp2-2 is a small molecule inhibitor of Skp2-Cks1 interaction with IC50 of 27.8 uM, significantly and dose-dependently reduces the protein expression of Skp2 in cancer cells.

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生物&药学活性

Skp2-2 is a small molecule inhibitor of Skp2-Cks1 interaction with IC50 of 27.8 uM, significantly and dose-dependently reduces the protein expression of Skp2 in cancer cells.
Skp2-2 increases the protein levels of p21 and p27, inhibit Skp2 expression up to 90%, in SGC-7901, a gastric cancer cell with high Skp2 expression.
Skp2-2 also influence the mRNA levels of Skp2, p21, and p27, showed significant S-phase arrest, with the proportion of S-phase.

物理化学性质&存储条件

分子量	298.36
分子式	C16H14N2O2S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1-phenyl-N-(quinolin-8-yl)methanesulfonamide

Skp2-2

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物理化学性质&存储条件

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Skp2-2

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物理化学性质&存储条件

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