Sivelestat sodium |CAS:150374-95-1 Probechem Biochemicals

Chemical Structure : Sivelestat sodium

CAS No.: 150374-95-1

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Sivelestat sodium (EI-546;LY-544349;ONO-5046)

货号: PC-45265Not For Human Use, Lab Use Only.

Sivelestat (EI-546;LY-544349;ONO-5046) sodium is a potent, specific and competitive inhibitor of human neutrophil elastase with IC50 of 44 nM.

规格	价格	库存
5 mg (Free Sample)	￥180	In stock
10 mg	￥780	In stock
25 mg	￥1280	In stock
50 mg	￥1980	In stock
100 mg		Get quote

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生物&药学活性

Sivelestat (EI-546;LY-544349;ONO-5046) sodium is a potent, specific and competitive inhibitor of human neutrophil elastase with IC50 of 44 nM.
Sivelestat also inhibits leukocyte elastase obtained from rabbit, rat, hamster and mouse, does not inhibit trypsin, thrombin, plasmin, plasma kallikrein, pancreas kallikrein, chymotrypsin and cathepsin G (>10 uM).
Sivelestat attenuates LPS-induced acute lung inflammation in the hamster.

物理化学性质&存储条件

分子量	456.4447
分子式	C20H21N2NaO7S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	Propanoic acid, 2,2-dimethyl-, 4-[[[2-[[(carboxymethyl)amino]carbonyl]phenyl]amino]sulfonyl]phenyl ester, sodium salt (1:1)

参考文献

1. Kawabata K, et al. Biochem Biophys Res Commun. 1991 Jun 14;177(2):814-20.

2. Yasui S, et al. Eur Respir J. 1995 Aug;8(8):1293-9.

3. Sakamaki F, et al. Am J Respir Crit Care Med. 1996 Jan;153(1):391-7.

Sivelestat sodium (EI-546;LY-544349;ONO-5046)

生物&药学活性

物理化学性质&存储条件

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Sivelestat sodium (EI-546;LY-544349;ONO-5046)

生物&药学活性

物理化学性质&存储条件

参考文献

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