Sirusertib (ACR-2316) | WEE1/PKMYT1 inhibitor | Probechem Biochemicals

Chemical Structure : Sirusertib

CAS No.: 3066062-53-8

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Sirusertib (ACR-2316, ACR2316)

货号: PC-27502Not For Human Use, Lab Use Only.

Sirusertib (ACR-2316) is a potent, selective dual WEE1/PKMYT1 (Myt1) inhibitor, shows potent WEE1 inhibition and robust activation of CDK1, CDK2, and PLK1, to induce potent tumor cell death.

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5 mg	￥3280	In stock
10 mg	￥5280	In stock
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生物&药学活性

Sirusertib (ACR-2316) is a potent, selective dual WEE1/PKMYT1 (Myt1) inhibitor, shows potent WEE1 inhibition and robust activation of CDK1, CDK2, and PLK1, to induce potent tumor cell death.

物理化学性质&存储条件

分子量	511.59
分子式	C27H29N9O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-allyl-6-((1-methyl-1H-indazol-5-yl)amino)-1-(6-((1-methylpiperidin-4-yl)oxy)pyridin-2-yl)-1,2-dihydro-3H-pyrazolo[3,4-d]pyrimidin-3-one

参考文献

1. Portia Lombardo, et al. Mol Cancer Ther (2025) 24 (10_Supplement): C112.

2. Patent WO2024254490 A1 2024-12-12.

Sirusertib (ACR-2316, ACR2316)

生物&药学活性

物理化学性质&存储条件

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Sirusertib (ACR-2316, ACR2316)

生物&药学活性

物理化学性质&存储条件

参考文献

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