Sironestrant (SIM0270) | SERD | Probechem Biochemicals

Chemical Structure : Sironestrant

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Sironestrant (SIM0270, SIM-0270)

货号: PC-27501Not For Human Use, Lab Use Only.

Sironestrant (SIM0270) is a brain-penetrant, oral selective estrogen receptor degrader (SERD), induces sustained inhibition of ER-dependent gene transcription and cell growth, shows antitumor activity in ESR1-mutant models and brain-metastatic models.

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生物&药学活性

Sironestrant (SIM0270) is a brain-penetrant, oral selective estrogen receptor degrader (SERD), induces sustained inhibition of ER-dependent gene transcription and cell growth, shows antitumor activity in ESR1-mutant models and brain-metastatic models.

物理化学性质&存储条件

分子量	489.56
分子式	C26H31F4N5
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3-Pyridinamine, N-[(3S)-1-(3-fluoropropyl)-3-pyrrolidinyl]-6-[(1S,3R)-2,3,4,9-tetrahydro-3-methyl-2-(2,2,2-trifluoroethyl)-1H-pyrido[3,4-b]indol-1-yl]-

参考文献

1. Patent WO2021228210 A1 2021-11-18.

2. Jian Zhang, et al. Clin Cancer Res (2025) 31 (12_Supplement): PS14-04.

Sironestrant (SIM0270, SIM-0270)

生物&药学活性

物理化学性质&存储条件

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Sironestrant (SIM0270, SIM-0270)

生物&药学活性

物理化学性质&存储条件

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